They can also affect the Painful tender breast, shape or sensitivity of cysts and fibroadenomas. Mastalgia can vary in intensity from a sharp pain to a mild tingling. Undergoing breast surgery and the formation of scar tissue can lead to breast pain. Causes, Treatment, and More. Breast pain can sometimes occur alongside changes in the menstrual cycle. You can also visit La Painful tender breast League International to find a certified lactation consultant in your area.